منابع مشابه
A cooperative water effect in proazaphosphatrane-catalysed heterocycle synthesis.
The synthesis of oxazolines and imidazolines was achieved by activation of isocyanides with water. Mechanistic studies show that the organosuperbase proazaphosphatrane is tolerant of water within the reaction medium, with a beneficial and cooperative effect being observed.
متن کاملPd-mediated synthesis of substituted benzenes fused with carbocycle/heterocycle.
A new Pd-catalyzed one-pot multicomponent coupling reaction for the construction of benzene ring fused with carbocycle or heterocycle under a Cu-free condition is described.
متن کاملSynthesis and antitubercular activity of heterocycle substituted diphenyl ether derivatives.
Despite being an ancient disease, tuberculosis (TB) remains the leading single-agent infectious disease killer in the world. The emerging serious problem of TB control and clinical management prompted us to synthesize a novel series of heterocyclic substituted diphenyl ether derivatives and determine their activity against the H37Rv strain of Mycobacterium. All ten compounds inhibited the growt...
متن کاملsynthesis of platinum nanostructures in two phase system
چکیده پلاتین، فلزی نجیب، پایدار و گران قیمت با خاصیت کاتالیزوری زیاد است که کاربرد های صنعتی فراوانی دارد. کمپلکس های پلاتین(ii) به عنوان دارو های ضد سرطان شناخته شدند و در شیمی درمانی بیماران سرطانی کاربرد دارند. خاصیت کاتالیزوری و عملکرد گزینشی پلاتین مستقیماً به اندازه و- شکل ماده ی پلاتینی بستگی دارد. بعضی از نانو ذرات فلزی در سطح مشترک مایع- مایع سنتز شده اند، اما نانو ساختار های پلاتین ب...
Mitigating heterocycle metabolism in drug discovery.
■ INTRODUCTION In the past few decades, drug metabolism research has played an ever increasing role in the design of drugs. In vitro metabolism assays have become an integral part of the routine profiling of compounds made in drug discovery. The data from these assays have allowed medicinal chemists to focus their efforts on compounds with improved metabolic stability. Detailed metabolite ident...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2020
ISSN: 1551-7012
DOI: 10.24820/ark.5550190.p011.273